VIM and neoplasm: Immunohistochemically, the tumor showed strong and diffuse staining for CD34, bcl-2, and vimentin; other markers, such as pan-cytokeratins, EMA, desmin, alpha-smooth muscle actin, and S-100 protein, were negative and had a high mitotic index (seven mitoses per 10 high-power fields (HPF)) (Figure 5).