2003; Gao et al. 2010; Case et al. 2013). Previous studies have shown that deletion of the AT1R from catecholaminergic neurons delays the onset of AngII-dependent hypertension and also reduces the maximal blood pressure response (Jancovski et al. 2013). In addition, catecholaminergic neurons, such as C1 neurons in the RVLM, play an important role in AngII-induced hypertension and blocking the AT1R specifically in these neurons can attenuate the AngII-mediated rise in blood pressure (Jancovski et al. 2014). This evidence concerns the gene AGTR1 and hypertensive disorder.