Dysregulation of angiotensin II (AngII)-dependent neuronal signaling in the central nervous system is involved in the pathogenesis of cardiovascular diseases, such as hypertension and chronic heart failure (Phillips and Sumners 1998; Veerasingham and Raizada 2003; Guyenet 2006; Zucker 2006). The gene discussed is AGT; the disease is Hypertension.