IRF1 and neoplasm: Some of the enriched transcription factors regulating the genes in bicluster B1 (associated with immune system responses in the human genome) include: HCLS1 gene that plays a key role in regulating clonal expansion and deletion in lymphoid cells [85], IRF1 protein that acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells [85], and TRIM22 antiviral protein involved in cell innate immunity [83].