IRF5 and cancer: Given that all three of these cytoskeletal molecules have been implicated in cancer migration, invasion and metastasis formation [33], in part, through their ability to participate in filamentous (F)-actin networking that is integral for cell motility [33,34], we examined F-actin networking in EV-231 and IRF5-231 cells and found distinct and condensed F-actin bundling at the nucleus of IRF5-231 cells as compared with EV-231 cells (Figure 6B).