It is unique in targeting the Raf/Mek/Erk (MAP Kinase) pathway [15], as HCC mainly involves overexpression of the RAF/MEK/ERK pathway [16] In addition, extracellular activation of VEGFR and PDGFR are involved in the formation of HCC and portal vein tumor thrombosis. This evidence concerns the gene MAP2K7 and hepatocellular carcinoma.