BRCA1 and breast cancer: Effective weight control interventions may help attenuate the rising breast cancer incidence within the general population (10-12% lifetime risk) [2,5] women with a family history of breast cancer and moderate/high risk (17-40% lifetime risk) [12-14] and women with high risk gene mutations (such as BRCA1/2) (60-80% lifetime risk) [15,16].