In addition, the lack of a defect in IKKβ-deficient T cell survival and proliferation in this tumor model allowed us to probe the role of NF-κB downstream of these early T cell priming events and identify an essential role for IKKβ in the acquisition of IFN-γ and TNF-α production by tumor-specific CD8+ T cells as well as of cytotoxicity in vivo. This evidence concerns the gene CD8A and neoplasm.