XCL2 and breast cancer: Ten genes involved in this pathway were up-regulated, including CXCL13, XCL2, XCL1, IL2, AMH, LTB, INHBE, TNFRSF18, CSF2 and IFNG. CXCL13 has been implicated in the progression of breast cancer [31], and the addition of lymphotactin (XCL1 and XCL2) has been shown to stimulate ovarian cancer cell migration and proliferation [32].