More interestingly, the most negatively correlated gene, AQP1 (R = -0.77, FC = -1.18, FDR = 1.54e-05), has been shown to be related to tumor progression [40] and high AQP1 expression has been demonstrated to be associated with better prognosis and improved overall survival outcome in renal tumor patients [41]. The gene discussed is AQP1; the disease is neoplasm.