How does IGF signaling, together with other extrinsic and intrinsic pathways (IL-6, Wnt, Hedgehog, BMPs, selectin, TGF-β, Alox5, CD25, among others) [9,28-33], regulate the fates of CML cells including self-renewal, differentiation, apoptosis, and migration? Here, ALOX5 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.