How does IGF signaling, together with other extrinsic and intrinsic pathways (IL-6, Wnt, Hedgehog, BMPs, selectin, TGF-β, Alox5, CD25, among others) [9,28-33], regulate the fates of CML cells including self-renewal, differentiation, apoptosis, and migration? This evidence concerns the gene IL6 and chronic myelogenous leukemia, BCR-ABL1 positive.