She returned 3 years later with T1c N0 M0, grade 3 estrogen receptor (ER) positive, progesterone receptor (PR) positive, HER2/neu negative, and Ki-67 20–25% infiltrating ductal carcinoma of the superior-medial quadrant of the right breast and underwent additional partial mastectomy and sentinel node biopsy followed by chemotherapy and radiation therapy. This evidence concerns the gene MKI67 and invasive ductal breast carcinoma.