We also observed a significant different in cumulative percentage of patients developing recurrence and distant metastasis in adenocarcinoma patients who had high and low Cystatin SN expression (P = 0.004), whereas this was not significantly different between high and low Cystatin SN groups in patients with SCC (P = 0.093) [Fig. 2(C–D)]. Here, CST4 is linked to adenocarcinoma.