GDF5 and hereditary disease: On the Online Mendelian Inheritance in Man database (OMIM), which collects human genes and genetic disorders with particular focus on the molecular relationship between genetic variation and phenotypic expression, the following polymorphisms and aspartic acid (D) repeats are reported as OA susceptibility (OS) sites: FRZB rs288326 (OS1A) and rs7775 (OS1B), MATN3 rs77245812 (OS2), ASPN D14 repeats (OS3), PTHR2 rs76758470 (OS4), GDF5 rs143383 (OS5) and DVWA rs11718863 (OS6) [19].