In summary, this study provided evidence that p14ARF, RASSF1A, p15INK4B (CDKN2B), RUNX3, GATA6, p16INK4A (CDKN2A), NDRG2 and to lesser extent ATM and RARβ promoter methylation are associated with the development of meningiomas. This evidence concerns the gene CDKN2A and meningioma.