In summary, this study provided evidence that p14ARF, RASSF1A, p15INK4B (CDKN2B), RUNX3, GATA6, p16INK4A (CDKN2A), NDRG2 and to lesser extent ATM and RARβ promoter methylation are associated with the development of meningiomas. The gene discussed is RUNX3; the disease is meningioma.