The increase per single unit of IL-8 leads to the increase in the value of PAI-1 by 0.02, while in CRS-4 the value of IL-8 was in a statistically significant correlation (P < 0.05) with PAI-1 and HDL (P < 0.01) (Table 7). This evidence concerns the gene SERPINE1 and craniosynostosis 4.