Intriguingly, they identified 10 new differentially methylated genes in infants whose mothers were smoking subjects, among them genes that are implicated in processes related to nicotine dependence and smoking cessation (FRMD4A-FERM domain containing 4A-ATP9A-ATPase, class II, type 9A) and placental and embryonic development (MEG3-maternally expressed 3). The gene discussed is MEG3; the disease is nicotine dependence.