Although in Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study the CD4+ cell count below 500 cells/μL was associated with increased risk of non-AIDS-related deaths [28], HIV Outpatient Study (HOPS) cohort reported 28% increased risk of CVD in patients with CD4+ count <500 cells/μL, regardless of the class of ART used [29]. Here, CD4 is linked to AIDS.