MT-ATP6 and neoplasm: Furthermore, tenofovir's negative effect on mitochondrial function could lead to impairment of tumor progenitor cell apoptosis (Modica-Napolitano et al., 2007; Ni Chonghaile et al., 2011), as has been specifically reported for loss-of-function mutations of mtATP6, a mitochondrial gene strongly suppressed by tenofovir in our study (Shidara et al., 2005).