DNMT1 and cancer: An association has been found between cruciferous vegetable intake and a reduced risk of various cancers (or level of biomarkers for specific cancers) in a number of human, animal and in vitro studies detailed as follows [17,139,140,141]: treatment of colon cancer cells with sulforaphane suppressed the expression of DNMT1 and increased the expression of genes involved in regulating cell cycle arrest and decreasing cell proliferation [141], and thus lowering cancer susceptibility.