Demethylation of these promoters leads to the decrease in expression of TRIM68 and PGK1 in prostate cancer cells, whilst methylation of the promoter of miRNA-29a led to increased expression of Myeloid cell leukemia sequence 1 (Mcl-1) which blocks apoptosis and supports cell survival in lymphoma [132]. Here, PGK1 is linked to Familial prostate cancer.