In prostate cancer the partial methylation of the aforementioned promoters down-regulates the expression of RARβ2 and CCND2, thereby increasing the expression of tripartite motif containing 68 (TRIM68) and phosphoglycerate kinase 1 (PGK1), which in turn promotes cell proliferation and invasion [66]. This evidence concerns the gene PGK1 and Familial prostate cancer.