Expression profiling had shown that miR-17 and miR-20a were overexpressed in varieties of solid tumors and hematopoietic malignancies, including MLL-rearranged leukemia [52], T-cell acute lymphoblastic leukemia [28, 53] and B-cell lymphoma [54, 55]. The gene discussed is KMT2A; the disease is T-cell acute lymphoblastic leukemia.