IRS2 and type 2 diabetes mellitus: SNP rs1411766 localizes to an intergenic region ~384 kb telomeric to MYO16 and 120 kb centromeric to IRS2. This SNP was reported increase susceptible to diabetic nephropathy, as determined by a GWAS in European-American subjects with type 1 diabetes [42] and was also observed to be associated with susceptibility to diabetic nephropathy in a Japanese population with type 2 diabetes [43].