The factor that lunasin also interacts with α5β1 integrin to suppress NF-κB in colon cancer cells [15] suggest that, in addition to macrophages, lunasin can exert its anti-inflammatory effect on airway epithelial cells and bronchial fibroblasts as the α5β1 integrin—NF-κB pathway is operating in these cell types [36, 37]. Here, NFKB1 is linked to colonic neoplasm.