Other up-regulated microRNAs included miR-335, functioning as a tumor suppressor in pancreatic cancer by targeting OCT4[31]; miR-133a/b, recently reported to inhibit proliferation, migration, invasion and cell cycle by targeting transcription factor SP1 in gastric cancer[32]; all members of miR-181 family, just like in high let-7a-2–3p expressers. The gene discussed is POU5F1; the disease is familial pancreatic carcinoma.