To directly address the hypothesis that the lack of steatosis in the Tsc1-/- liver is a result of Akt suppression, we deleted the dual-specific phosphatase, Pten, in hepatocytes of the Tsc1fl/fl;AlbCre mice to force Akt activation and overcome mTORC1-induced inhibition of PI3K/Akt. Here, PTEN is linked to steatosis.