IRF3 and viral infectious disease: Host innate immune response is critical against virus; therefore, we examinedwhether temperature affected viral infection-mediated innate immune activation.Interferon (IFN) regulatory factor 3 (IRF3) plays a key role in virus triggeringinnate immunity activation; it coordinates with NFκB p65 subunit andc-Jun/AP1 to bind the type I IFN promoter region to induce type I IFNtranscription [41,42,43].