SOD2 and neoplasm: Our results confirm recent studies which demonstrated that the tumor suppressor ability of hsa-miR-17-3p is correlated with the downregulation of the three critical primary mitochondrial antioxidant enzymes: manganese superoxide dismutase (MnSOD), glutathione peroxidase-2 (GPX-2) and thioredoxin reductase (TrxR2) (29).