NEDD9 and pachyonychia congenita: More importantly, a significant negative correlation was observed between miR-145 and NEDD9 expression in PC tissues, and the expression of NEDD9 was decreased in Panc-1 cells accompanied by suppressed cell proliferation, invasion and migration when overexpressing miR-145, suggesting that miR-145 may be involved in the regulation of NEDD9 in PC.