Notably, it was identified that neural precursor cell expressed, developmentally downregulated 9 (NEDD9, also termed HEF1 or Cas-L), a non-catalytic scaffolding protein implicated in the invasive ability of several types of cancer (15,16), is a novel target of miR-145 in PC. The gene discussed is NEDD9; the disease is pachyonychia congenita.