Furthermore, miRNAs (miR-125a-5p, miR-331–3p, miR-17, miR-150, miR-155, miR-27b, miR-31, miR-92a and miR-509–5p), which differentially expressed in gastric cancer, were found to regulate expression of E2F1, E2F2, E2F5 and E2F7 in this study (S3 Table). The gene discussed is E2F1; the disease is gastric cancer.