Incidence of any hypoglycaemia was lowest in patients receiving to Met/Incr (6.5%) and it was substantially higher in those receiving Met/SU (15.4%; OR 2.70; 95% CI 1.48–4.92) or insulin (37.1%; OR 8.35; 95% CI 4.84–14.4). The gene discussed is INS; the disease is Hypoglycemia.