With regard to the tumor adjacent (apparently normal) tissues and hyperplasia that displayed no staining or faint staining of pS9GSK3β and pS21GSK3α in the cytoplasmic regions, it seems that inactive GSK3α/β expression in the cytoplasm contributes to tumor progression whereas nuclear expression of inactive GSK3α/β leads to a more severe disease. Here, GSK3A is linked to neoplasm.