NOX4 and Parkinson disease: Such increases in the nuclear Nox4 expression were accompanied by similar increases in oxidative stress-induced damage to neuronal nucleic acids as demonstrated by elevated immunodetection of StressMarq signature of oxidized guanosine (8-hydroxy guanosine; 8-OH guanosine) in the nuclei of dopamine neurons (Figure 7E-G) with a progressive pattern: 31% for AMC < 68% for prePD < 82% for PD (Figure 7H).