TH and Parkinson disease: Our observation that the decline in the AT1 expression in the matrix, a structure with a relative to nigrosome 1 sparing of dopamine neurons in PD (Figure 4 and [23]), is greater than that in the more affected nigrosome 1 where we detected a significant loss of TH+ neurons in both prePD as well as in PD cases, suggests that probability that neurons survive increases in association with lower total (Figure 4) as well as nuclear (Figure 5) AT1 expression.