Selected genes of interest in the tumor signature, including VEGFA, VEGFC, CD44, CDH1, MMP2, MMP9, TIMP1, CTNNB1, GADD45B, MYBL2, IGF2R, and NME1, are known to be involved in angiogenesis, metastasis, and prognosis. This evidence concerns the gene MMP9 and neoplasm.