Even Vinciguerra M et al. have suggested that liver-specific PTEN knockout mice were hypersensitive to insulin in spite of the development of steatosis and steatohepatitis [13], the role of PTEN in hepatic steatosis with IR, which is more common in HCV infection than in other chronic inflammatory liver diseases, is still a matter of debate. The gene discussed is PTEN; the disease is steatosis.