CRKL and chronic myelogenous leukemia, BCR-ABL1 positive: For the KOs of Bcr-Abl to CrkL and Bcr-Abl to Pag, WT cells remained at the normal baseline behavior, while CP CML cells reduced both proliferation and self-renewal capacity levels to 1 (with apoptosis remaining at 0) and BC CML cells reduced proliferation level to 1 (with apoptosis remaining at 0).