For the KOs of Bcr-Abl to Abi1 and Abi2 and Bcr-Abl to CrkL, WT cells remained at their baseline cell behaviors, while CP CML cells reduced both proliferation and self-renewal capacity levels to 1 (but apoptosis remained at 0) and BC CML cells reduced the proliferation (and had apoptosis at 0). The gene discussed is CRKL; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.