BCL2L1 and chronic myelogenous leukemia, BCR-ABL1 positive: The other four successfully replicated experiments included the observations that MEK-ERK activation of HNRPK is not required for cytokine independent proliferation, that Interleukin-3 (IL-3) upregulation induces factor independent growth in leukemic cells, that Bcl-XL suppression induces apoptosis in CML cells, and that Bcr-Abl conveys the ability for CML cells to have factor-independent growth17, 18, 19, 20.