NTSR1 activates at least three major pathways in cancer, which are small GTPases activation inducing cellular mobility, intracellular Ca2+ mobilization involving in gene regulation and proto-oncogene serine/threonine-protein kinase/mitogen-activated protein kinase/extracellular signal-regulated kinase (Raf-1/Mek/Erk) cascade inducing cell proliferation [6]. This evidence concerns the gene NTSR1 and cancer.