NLRP3 and periodontitis: Data obtained in differentiated THP-1 cells infected with Porphyromonas gingivalis, the major pathogen involved in the pathogenesis of periodontitis [73], evidenced that the microorganism induces IL-1β secretion, caspase-1 activation and pyroptotic cell death through both NLRP3 and AIM2 inflammasome activation [74].