Thereto, the ephrin-A1 induction was examined in three prostate cancer cell lines (LNCaP clone GFC derived form lymph node39, DU 145 from brain leson40 and MDA PCa 2b from bone metastasis41) and one prostate derived cell line (WPE1-NB2642) using our SCFS assay (Supplementary Fig. 5). This evidence concerns the gene EFNA1 and Familial prostate cancer.