The 19q13.32 region has long been associated with AD and more recently was associated with non-pathological cognitive aging;28 the 6q16.1, 14q12 and HMGN1 regions contain genes associated with development of the brain,78, 79 neurological function,71, 72, 79 psychiatric disease73, 74, 75, 76 and educational attainment.35 This evidence concerns the gene HMGN1 and Alzheimer disease.