MECP2 and autism spectrum disorder: The significant finding from the gene-based analysis, HMGN1 (high mobility group nucleosome-binding domain 1), encodes a nucleosome-binding protein that is associated with transcriptionally active chromatin.77HMGN1 negatively regulates methyl CpG-binding protein 2 (MeCP2), a DNA-binding protein that is mutated in the neurodevelopmental disorder Rett syndrome78 and is known to affect neurological functions including X-linked mental retardation, various autism spectrum disorders in humans and the behavior of mice.