Supplementary Table S5 shows the gene-based association results for 29 genes previously reported to be associated with AD or neuropathologic features of AD and related dementias.38, 39, 40, 41, 42, 43, 44 Four of these genes, TOMM40, APOE, MEF2C and ABCG1, were associated with general fluid cognitive function at P<0.01. The gene discussed is MEF2C; the disease is dementia.