NPAS3 and learning disability: The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis.71 It has been associated with brain development and potentially human brain evolution.72 A balanced reciprocal translocation t(9,14)(q34.2;q13) that disrupts NPAS3 was identified in a mother and daughter with schizophrenia and schizophrenia co-morbid with mild learning disability, respectively.73, 74 A GWAS has since reported three coding SNPs (rs12434716, c.1654G>C, P=0.009; rs10141940, c.2208C>T, P=0.01; and rs10142034, c.2262C>G, P=0.01) to be associated with schizophrenia.75