ID2 and B-cell chronic lymphocytic leukemia: Finally, the drug, ethacrynic acid, which in contrast to fludarabine and chlorambucil, acts at least in part through inhibition of the Wnt/β-catenin signalling pathway [30] that is also known to be a key regulator of ID gene expression [2,3] (and was also inferred from pathway enrichment analysis of ID2 MIC ‘targets’ in CLL – see Additional file 6: Table S4).