KLF4 and acute lymphoblastic leukemia: To detect potential direct KLF4 target genes in T-ALL, we selected KLF4-repressed candidate genes identified from RNA-seq analysis (Additional file 3: Table S2) that contained KLF4 motif in the promoter regions [42] or were identified by ChIP-seq analysis as direct Klf4 target genes in a mammary epithelial cell line [43] for ChIP validation.