Probing various publicly available datasets (GSE20347, GSE47404, GSE13937) to assess the expression of SOX4, EZH2 and HDAC3 in primary esophageal squamous and adenocarcinoma samples, we found SOX4 and EZH2 to be significantly upregulated in ESCC tumor samples (GSE20347), compared to normal tissues (Figure 7B). Here, HDAC3 is linked to esophageal squamous cell carcinoma.