Meta-analysis has identified SOX4 as one of the 64 genes that constitute a general signature in all human cancers, and genome wide promoter analysis has shown that SOX4 regulates the transcription of genes involved in TGF-β, Wnt, Hedgehog, and Notch pathways and components of miRNA processing machinery such as Dicer, Argonaute 1 and RNA Helicase A [28,29]. The gene discussed is SOX4; the disease is cancer.