PHB2 and kidney disorder: To understand the contribution of mitochondrial dysfunction to kidney disease, we deleted the Phb2 gene specifically in podocytes (Phb2pko) by mating a conditional Phb2fl/fl mouse line (Merkwirth et al, 2008) to podocyte-specific Cre mice (NPHS2.cre) (Moeller et al, 2003).