Equally compelling is the association of PRELID1 with the right branch of B-PC2 where inhibition of Th2 cell development [28] potentially reduces the contribution of adaptive immunity to asthma (Fig. 3B); subjects in Leaf 1 where Th2 cell-activated eosinophils and lymphocytes dominate have the complementary absence of any PRELID1-induced protection. This evidence concerns the gene PRELID1 and asthma.