EGFR and breast carcinoma: More recently, it has become clear that the Hippo pathway can regulate proliferation non-autonomously: Hippo signaling regulates secretion of JAK/STAT and EGFR ligands in Drosophila intestinal stem cells [37,38,39], and of EGFR ligands in breast cancer cell lines [31], and the resulting changes in ligand levels affect the proliferation of surrounding cells non-autonomously.