YAP1 and germ cell tumor: In contrast, we observed that yki controls proliferation of the larval GCs, albeit independently of hpo and wts. These contrasting results are likely due to the fact that Sun et al. [35] sought to detect conspicuous germ cell tumors in response to reduced Hippo pathway activity, whereas we manually counted GCs and in this way detected significant changes in GC number in response to yki knockdown or overexpression.