FMR1 and dementia: Keeping in mind that a family history should be checked, but also that the family history may be negative for clear FMR1 related disorders, health care professionals should consider gene testing if a patient over age 50 has unexplained cerebellar gait ataxia, unexplained action tremor and dementia, or the MCP or CCS hyperintensity on MRI and some FXTAS signs, as in Table 2.