BIRC3 and cancer: RNA-Seq data from B-cell lymphomas demonstrated an almost complete reduction of TRPC6 transcript suggesting cis-regulation by the 29 Mb risk haplotype, which also reduced the expression of three other genes in the region BIRC3, ANGPTL5, and KIAA1377. BIRC3 encodes an anti-apoptotic protein associated with B-cell malignancies and other cancers [39], ANGPTL5 is a member of the angiopoietin growth factor family [40], while KIAA1377 is a novel centrosomal protein required for cytokinesis [41].