FCN2 and rheumatic fever: Although there are few investigations of the role of L-ficolin in viral infections, FCN2 polymorphisms were found to be significant in susceptibility to and disease severity of bacterial diseases, including cutaneous leishmaniasis [152], Mycobacteriumleprae [153], Pseudomonas aeruginosa-associated bronchiectasis [154], and Streptococcus pygones-associated rheumatic fever and chronic rheumatic heart disease [155].