In conclusion, in patients with obesity and type 2 diabetes, insulin infusion leads to a suppression of the expression of IL-4, ADAM-33, LIGHT, and LTBR in parallel with a reduction in plasma NOM, TGFβ, MCP-1, and MMP-9 concentrations. This evidence concerns the gene TGFB1 and obesity due to melanocortin 4 receptor deficiency.