KCNMA1 and central nervous system cancer: KCa1.1 channels are expressed as a particular splicing isoform in GBM cells (the glioma BK, gBK; Liu et al., 2002), and are implicated in GBM invasion (Bordey et al., 2000; Wondergem and Bartley, 2009; Cuddapah and Sontheimer, 2011; Steinle et al., 2011).