It has been shown that AVD in D54-MG glioma cells is dependent on a DIDS-sensitive chloride conductance (Ernest et al., 2008), and a K+ efflux mediated by Ca2+-activated K+ channels, KCa3.1 and KCa1.1 (McFerrin et al., 2012). This evidence concerns the gene KCNMA1 and central nervous system cancer.