Thus, in the present study, we investigated the effects of miR-221 and miR-222 mimics on six lung cancer cell lines with diverse molecular alterations (three epidermal growth factor receptor (EGFR) mutant and three EGFR wild type cell lines) as well as one Cdk4/hTERT-immortalized normal human bronchial epithelial line, HBEC4 19–22. The gene discussed is EGFR; the disease is lung carcinoma.