However, as immunization with vaccinia virus can lead to potent nonspecific priming of the immune system, it was important to demonstrate that the partial tumor control observed in Vac-LMP2A-immunized mice was not due to a bystander effect of vaccinia-specific T cells, but rather due to specific targeting of tumor-expressed LMP2A by LMP2A-specific CD8+ T cells. Here, CD8A is linked to neoplasm.